Ebenezer Cooke (fl. c1708) was a poet, born in London, who later emigrated to Maryland in what is now the United States of America. He was the author of a satirical poem, The Sotweed Factor, or A Voyage to Maryland, A Satyr, and not a great deal else is known about him.

Nevertheless, author John Barth took the little biographical detail that exists, and used it for the basis of his own satire, a novel entitled The Sot-Weed Factor (1960).

In turn, Philip José Farmer drew on Barth's novel for parts of the geneaology described in Doc Savage: His Apocalyptic Life, notably that Ebenezer Cooke and his sister Anna Cooke were the children of Andrew Cooke, himself the son of another Andrew Cooke. Anna was the son of yet another Andrew Cooke, whom Farmer identifies as an ancestor of Kilgore Trout.

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